Glucose Metabolism in T Cells and Monocytes: New Perspectives in HIV Pathogenesis.
Identifieur interne : 000B81 ( Main/Exploration ); précédent : 000B80; suivant : 000B82Glucose Metabolism in T Cells and Monocytes: New Perspectives in HIV Pathogenesis.
Auteurs : Clovis S. Palmer [Australie] ; Catherine L. Cherry [Afrique du Sud] ; Isabel Sada-Ovalle [Mexique] ; Amit Singh [Inde] ; Suzanne M. Crowe [Australie]Source :
- EBioMedicine [ 2352-3964 ] ; 2016.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Glucose (métabolisme), Grippe humaine (immunologie), Grippe humaine (métabolisme), Humains, Infections à VIH (immunologie), Infections à VIH (métabolisme), Infections à virus Epstein-Barr (immunologie), Infections à virus Epstein-Barr (métabolisme), Lymphocytes T (métabolisme), Monocytes (métabolisme), Stress oxydatif, Voies et réseaux métaboliques, Évolution de la maladie.
- MESH :
- immunologie : Grippe humaine, Infections à VIH, Infections à virus Epstein-Barr.
- métabolisme : Glucose, Grippe humaine, Infections à VIH, Infections à virus Epstein-Barr, Lymphocytes T, Monocytes.
- Activation des lymphocytes, Humains, Stress oxydatif, Voies et réseaux métaboliques, Évolution de la maladie.
English descriptors
- KwdEn :
- Disease Progression, Epstein-Barr Virus Infections (immunology), Epstein-Barr Virus Infections (metabolism), Glucose (metabolism), HIV Infections (immunology), HIV Infections (metabolism), Humans, Influenza, Human (immunology), Influenza, Human (metabolism), Lymphocyte Activation, Metabolic Networks and Pathways, Monocytes (metabolism), Oxidative Stress, T-Lymphocytes (metabolism).
- MESH :
- chemical , metabolism : Glucose.
- immunology : Epstein-Barr Virus Infections, HIV Infections, Influenza, Human.
- metabolism : Epstein-Barr Virus Infections, HIV Infections, Influenza, Human, Monocytes, T-Lymphocytes.
- Disease Progression, Humans, Lymphocyte Activation, Metabolic Networks and Pathways, Oxidative Stress.
Abstract
Activation of the immune system occurs in response to the recognition of foreign antigens and receipt of optimal stimulatory signals by immune cells, a process that requires energy. Energy is also needed to support cellular growth, differentiation, proliferation, and effector functions of immune cells. In HIV-infected individuals, persistent viral replication, together with inflammatory stimuli contributes to chronic immune activation and oxidative stress. These conditions remain even in subjects with sustained virologic suppression on antiretroviral therapy. Here we highlight recent studies demonstrating the importance of metabolic pathways, particularly those involving glucose metabolism, in differentiation and maintenance of the activation states of T cells and monocytes. We also discuss how changes in the metabolic status of these cells may contribute to ongoing immune activation and inflammation in HIV- infected persons and how this may contribute to disease progression, establishment and persistence of the HIV reservoir, and the development of co-morbidities. We provide evidence that other viruses such as Epstein-Barr and Flu virus also disrupt the metabolic machinery of their host cells. Finally, we discuss how redox signaling mediated by oxidative stress may regulate metabolic responses in T cells and monocytes during HIV infection.
DOI: 10.1016/j.ebiom.2016.02.012
PubMed: 27211546
Affiliations:
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Palmer</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Biomedical Research, Burnet Institute, Melbourne, Australia; Department of Infectious Diseases, Monash University, Melbourne, Australia. Electronic address: cpalmer@burnet.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Biomedical Research, Burnet Institute, Melbourne, Australia; Department of Infectious Diseases, Monash University, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Cherry, Catherine L" sort="Cherry, Catherine L" uniqKey="Cherry C" first="Catherine L" last="Cherry">Catherine L. 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Energy is also needed to support cellular growth, differentiation, proliferation, and effector functions of immune cells. In HIV-infected individuals, persistent viral replication, together with inflammatory stimuli contributes to chronic immune activation and oxidative stress. These conditions remain even in subjects with sustained virologic suppression on antiretroviral therapy. Here we highlight recent studies demonstrating the importance of metabolic pathways, particularly those involving glucose metabolism, in differentiation and maintenance of the activation states of T cells and monocytes. We also discuss how changes in the metabolic status of these cells may contribute to ongoing immune activation and inflammation in HIV- infected persons and how this may contribute to disease progression, establishment and persistence of the HIV reservoir, and the development of co-morbidities. We provide evidence that other viruses such as Epstein-Barr and Flu virus also disrupt the metabolic machinery of their host cells. Finally, we discuss how redox signaling mediated by oxidative stress may regulate metabolic responses in T cells and monocytes during HIV infection. </div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Australie</li><li>Inde</li><li>Mexique</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Palmer, Clovis S" sort="Palmer, Clovis S" uniqKey="Palmer C" first="Clovis S" last="Palmer">Clovis S. Palmer</name></region><name sortKey="Crowe, Suzanne M" sort="Crowe, Suzanne M" uniqKey="Crowe S" first="Suzanne M" last="Crowe">Suzanne M. Crowe</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Cherry, Catherine L" sort="Cherry, Catherine L" uniqKey="Cherry C" first="Catherine L" last="Cherry">Catherine L. Cherry</name></noRegion></country><country name="Mexique"><noRegion><name sortKey="Sada Ovalle, Isabel" sort="Sada Ovalle, Isabel" uniqKey="Sada Ovalle I" first="Isabel" last="Sada-Ovalle">Isabel Sada-Ovalle</name></noRegion></country><country name="Inde"><noRegion><name sortKey="Singh, Amit" sort="Singh, Amit" uniqKey="Singh A" first="Amit" last="Singh">Amit Singh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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